منابع مشابه
Piezo channels
Parpaite and Coste introduce Piezo channels and their role in mechanotransduction.
متن کاملMechanosensitive Channels: In Touch with Piezo
Mechanosensory transduction underlies touch, hearing and proprioception and requires mechanosensitive channels that are directly gated by forces; however, the molecular identities of these channels remain largely elusive. A new study has identified Piezo1 and Piezo2 as a novel class of mechanosensitive channels.
متن کاملIon Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels
Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our finding of the miniature pore-forming module of Piezo1 that resembles the pore arc...
متن کاملTuning Piezo ion channels to detect molecular-scale movements relevant for fine touch
In sensory neurons, mechanotransduction is sensitive, fast and requires mechanosensitive ion channels. Here we develop a new method to directly monitor mechanotransduction at defined regions of the cell-substrate interface. We show that molecular-scale (~13 nm) displacements are sufficient to gate mechanosensitive currents in mouse touch receptors. Using neurons from knockout mice, we show that...
متن کاملPiezo - Smart Roads
In order to satisfy the rising energy demands of global consumption, a new cleaner and renewable power source needs to be explored, conceptualized and developed. This paper intends to introduce an alternative source of energy by using piezoelectric material -a class of smart material. A piezoelectric road that will produce electricity from the stress experienced by the roads due to the movement...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2017
ISSN: 0960-9822
DOI: 10.1016/j.cub.2017.01.048